Enter pH and concentrations to calculate pKa.
Formula:
pKa = pH - log10([A⁻]/[HA])
The pKa Calculator is designed to make acid-base calculations simple and accurate. With a clean interface, users can either enter their own values or select common acids and bases.
This tool is essential for students, chemists, and researchers working in labs. Understanding the strength of acids and bases is critical for predicting reaction behavior.
By providing real-time calculations, the calculator ensures quick feedback. Users can instantly see how pH and concentrations affect the pKa value.
The pKa of a substance represents the acid dissociation constant on a logarithmic scale. It measures how easily an acid donates a proton to a base.
Lower pKa values indicate strong acids that dissociate easily. Higher pKa values correspond to weaker acids that hold onto their protons.
Using this calculator, you can quickly compare different acids and determine their relative strengths. It is particularly useful in titration experiments and buffer preparation.
The Henderson-Hasselbalch equation is the core of this calculation:
pKa = pH - log10([A⁻]/[HA])
Here, [A⁻] is the concentration of the conjugate base, and [HA] is the concentration of the acid. By entering these values, the calculator computes pKa instantly.
Here are some practical examples to help you understand pKa calculations:
| Acid | pKa | Strength |
|---|---|---|
| Acetic Acid | 4.76 | Weak Acid |
| Formic Acid | 3.75 | Weak Acid |
| Hydrochloric Acid | -7 | Strong Acid |
| Sulfuric Acid | -3 | Strong Acid |
| Phosphoric Acid | 2.15 | Moderate Acid |
| Lactic Acid | 3.86 | Weak Acid |
| Citric Acid | 3.13 | Weak Acid |
This table provides a quick reference for commonly used acids and their pKa values. It helps to quickly identify acid strength and plan experiments.
| Base | pKa (Conjugate Acid) | Strength |
|---|---|---|
| Ammonia | 9.25 | Moderate Base |
| Sodium Hydroxide | 15.7 | Strong Base |
| Potassium Hydroxide | 15.7 | Strong Base |
| Methylamine | 10.64 | Moderate Base |
| Ethanolamine | 9.5 | Moderate Base |
| Pyridine | 5.23 | Weak Base |
| Imidazole | 7.0 | Weak Base |
Understanding the pKa of conjugate acids allows for predicting reaction equilibria. It helps in buffer design and predicting the ionization of bases in solution.
| Buffer | pKa | Usage Range |
|---|---|---|
| Acetic Acid/Acetate | 4.76 | pH 3.76-5.76 |
| Phosphate | 7.2 | pH 6.2-8.2 |
| Bicarbonate | 6.37 | pH 5.37-7.37 |
| Tris | 8.1 | pH 7.1-9.1 |
| HEPES | 7.55 | pH 6.55-8.55 |
| MES | 6.1 | pH 5.1-7.1 |
| Glycine | 9.6 | pH 8.6-10.6 |